Morphologic confounders and CD19 negativity in a case of hairy cell leukemia.

Morphologic Confounders and CD19 Negativity in a Case of Hairy Cell Leukemia

OBJECTIVES We report a case of hairy cell leukemia (HCL) initially misdiagnosed as plasma cell dyscrasia due to various clinical, morphological and immunophenotypic confounders. METHODS AND RESULTS In a patient diagnosed of marrow plasmacytosis and serum monoclonal protein elsewhere and referred to our hospital, morphological evaluation of bone marrow aspirate smears and trephine biopsy, immu...

Hairy Cell Leukemia in a Young Male: An Unusual Presentation

Dear Editor-in-Chief A 28 yr male was presented in October 2015 at Medicine Outpatient Department, Safdarjung Hospital, New Delhi- India with generalized weakness, fever and cough for preceding 15 days. Clinicoradiologic examination revealed pallor, firm, non-tender splenomegaly measuring 13.7 cm and hepatomegaly (liver span - 16.9 cm). However, no lymphadenopathy was found.

A case of hairy cell leukemia variant.

Hairy cell leukemia variant (HCLv) is a rare B-cell chronic lymphoproliferative disorder with features of the classic HCL but presenting some particularities, a poor response to conventional therapy of classic HCL and a more aggressive course of disease with shorter survival than classic HCL. We present a case of a 52-year-old man hospitalized in July 2012 in the Clinic of Hematology of Craiova...

Case 4: Hairy Cell Leukemia

Hairy cell leukemia: a case report.

Hairy cell leukemia (HCL) is a relatively rare, chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia and bone marrow infiltration by hairy cells with circumferential prominent hairy cytoplasmic projections. Splenomegaly with few atypical lymphoid cells in peripheral blood lead to the examination of bone marrow for morphological findings characteristic of hairy...